Selasa, 24 Desember 2013

Free Ebook

Free Ebook

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Product details

File Size: 1995 KB

Simultaneous Device Usage: Unlimited

Publication Date: November 3, 2016

Sold by: Amazon Digital Services LLC

Language: English

ASIN: B01M5KDV60

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Amazon Best Sellers Rank:

#1,090,499 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

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Senin, 23 Desember 2013

PDF Download The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

PDF Download The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

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The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level


The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level


PDF Download The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

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The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

Product details

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Audible Audiobook

Listening Length: 9 hours and 43 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: HighBridge, a division of Recorded Books

Audible.com Release Date: May 14, 2013

Whispersync for Voice: Ready

Language: English, English

ASIN: B00C7DXYHY

Amazon Best Sellers Rank:

Today's news reporting and book literature is slowly reflecting the emerging cancer research and treatment landscape - targeted, specific and narrowly effective. The first book I read that described this new cancer universe was "Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer."In "Philadelphia Chromosome," author Jessica Wapner describes how chronic myeloid leukemia (CML) went from a painful and fairly rapid death sentence to a largely chronic condition managed through Gleevec, an orally-administered drug that targets cancer at its genetic level.Wapner writes a gripping, yet restrained, tale that recognizes both the promise and limits of this new approach to the age-old problem of cancer. She profiles Brian Drucker, the doctor who championed the development of the drug, as saying, "if I told you I could give you a pill that was going to put your cancer in remission with no side effects, would you believe it?"For the 5,000 patients diagnosed each year with CML in the U.S., the answer happily is, "yes." And given the devastating side effects and oftentimes futile results from the mainline cytotoxic cancer treatments, the answer desperately needs to be "yes." Wisely, though, as tempting as it is to extrapolate the miraculous success of Gleevec to larger arenas in which the cancer fight is still taking place, Wapner doesn't overreach.For this reason, besides the outstanding reporting that narrates the personalities, forces and science that unraveled this complex disease and discovered its one-of-a-kind cure, Wapner's book gets 5 stars.

This book was well written and understandable to a non-scientist, such as myself. That is not to say, however, that I wasn't sometimes confused about how all the different people whose discoveries came together to lead to the discovery of Gleevec fit together. The author jumps back and forth a bit and there were a lot of names and patients to keep track of, and I had to stop and try to recall who we were talking about. And I'm not a biochemist and since my chemistry in high school days are long gone, I had to look up a bunch on wikipedia to refresh my recollection of cellular processes. Although, I'm not saying that this book isn't well written. Far from it. The author uses good analogies to help the reader understand the cellular processes. Without that help, I would have been lost.The Philadelphia chromosome has had an unfortunate effect on my family. I have had a 3rd cousin die from leukemia who had received a bone marrow transplant, a first cousin die from cml with the philadelphia chromosome, and a nephew with ALL with the philadelphia chromosome survive because he got to take Gleevec. My first cousin with CML went into blast stage a short couple of months after Gleevec was featured on the news and he was unable to get the medicine that would have saved his life. So, this topic is very real and personal one to me and this book helped me to understand the process of the disease and the miracle of the discovery this book speaks of. I just wish the 3 years of stalling on the beginning of trials had not existed, because those were the 3 years that my cousin could have got on the trial and lived. He left four children and a wife. He was the sole support and comfort of his family. I miss him.

This really was a great book for me to read. I loved doing research in med school. But I've been teaching for several years premed and nursing students. I had heard about the Philadelphia Chromosome in all of my textbooks, but they don't say as much about it as they could have...so I absolutely needed to read this book. I don't think people realize the amount of time and work it takes from having an inkling about something going strange in the human body, and taking it to a conclusion that will possibly help people. USually it takes decades and many, many groups and people involved in figuring several different pathways to the same ending to finally decode where the problem lies.Chronic myelogenous leukemia is one of the nastier cancers out there. I knew people who got this and died from it. There was almost nothing to treat it. It was like pancreatic cancer is now...we would kind of shake our heads, and cry...because it was a death sentence. But there was someone who really observed what was happening between two chromosomes. Usually when we copy chromosomes they don't have a problem, but every once in a while, a chromosome will delete something or invert something...and what gets made by that chromosome (DNA goes to RNA goes to proteins) gets made wrong. In this case, it was an enzyme...and that enzyme led towards cancer. CML is usually an older person's disease. Why? Because as we get older, our ability to repair mistakes in our cells get significantly less.This book follows the many great people and corporations who worked on this problem, in order to find something that would heal this disease. I'm impressed with the story, impressed with the people. And I was impressed with the wriiting of the author. A much needed to book for people who know nothing about doing research. REsearchers do not get the fame they should ever...but they should!Having said all this about this being a great book...I didn't like the ending of the book because it sounded like a shill for the pharmaceutical companies. Most research is done by universities, and the pharmaceutical companies usually get the end of the research and make money off of it. I do admit the corporations here did a lot more than many of them do...but it really makes me wonder if this book was paid for originally by the companies pushing this particular drug. It saves lives, but to me this smacked of a book that was subsidized to make Big Pharma look good, when currently they do way too many things wrong.

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Minggu, 15 Desember 2013

Free Ebook Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander

Free Ebook Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander

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Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander

Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander


Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander


Free Ebook Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander

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Remembered (Fountain Creek Chronicles, Book 3) (Volume 3), by Tamera Alexander

Review

2008 Christy Award Winner "Tamera Alexander's characters are real, fallible, and a marvelous reflection of God's truth and grace. Her stories unfold layer-by-layer, drawing you in deeper with every page." - Armchair Interviews"A rich historical by possibly the best new writer in this subgenre..." - Library Journal"Alexander has written a charming historical romance that features well-drawn characters and smooth, compelling storytelling that will have readers anxiously awaiting the second installment of the Fountain Creek Chronicles. Highly recommended..." -- Library Journal (STARRED review) about Revealed"It's a pleasure to read this debut book. Rich prose, a realistic setting and characters, and a compassionate story of love will keep you turning the pages long into the night." - Romantic Times Top Pick (4 1/2 stars) about Revealed

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About the Author

Tamera Alexander (www.tameraalexander.com) is a USA Today bestselling novelist whose deeply drawn characters, thought-provoking plots, and poignant prose resonate with readers worldwide. She and her husband make their home in Nashville. Tamera invites you visit her at her website, her blog, Twitter, or Facebook.

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Product details

Paperback: 384 pages

Publisher: Bethany House Publishers; Reprinted edition (June 1, 2007)

Language: English

ISBN-10: 9780764201103

ISBN-13: 978-0764201103

ASIN: 0764201107

Product Dimensions:

5.5 x 1 x 8.4 inches

Shipping Weight: 10.4 ounces (View shipping rates and policies)

Average Customer Review:

4.7 out of 5 stars

154 customer reviews

Amazon Best Sellers Rank:

#859,382 in Books (See Top 100 in Books)

Ms. Alexander's books are genuine and especially Scripturally sound. I commend her for the inspirational effect of her writing style. Most of the characters thought processes are complicated and on occasion confusing, but resolved later. The mystery is intriguing, and I highly recommend the reader take the time and commitment to delve into this story. You will experience tearful and joyful emotions, which add to the truth-lending feature of fictional writing. The romance is rather slow in the development process, though endearing. God bless you, Tamera, for your faithfulness to God's Word.

I was surprised after reading the first two books to see who the main characters were in this book, but it was a pleasant surprise. I found the plot a little confusing. I never really understood why the heroine's benefactor was willing to give her so much money. It seemed strange to me. The interaction between Jack and Veronique I found quite entertaining. I really enjoyed the character development. My greatest disappointment was in the conclusion of the book. Without giving away spoilers, I thought the book ended very abruptly. I finished one chapter and turned the page only to find that the book was over. Sure there is an epilogue that summarizes a few things, but these are the very things I wanted to read about, not have summarized. I still enjoyed the book, but wished the author would have included a couple more chapters. If the length was a concern there were definitely parts earlier in the book that could have been left out in order to have a more satisfying conclusion. All in all it is a good conclusion to this trilogy with satisfactory updates on all the beloved characters of the previous books. I would have given this a five star rating up until the final chapter.

I have to say that the author is going downhill with her books of this series. "Rekindled" was a remarkable read. "Revealed" was good as well. "Remember" comes short to fulfill expectations of a reader who was much impressed with the first and second book of the series. This book did not hold much interest. It was not powerful. It was just a very simple read that did not hold much of my attention until the end of the book. The last sixty pages of the book were great. I was going to return the book without finishing it, but I am glad that I have read the ending. It was the best part from the whole book! But this book was nothing compared to her previous books. You feel much of an outsider of the story until almost towards the end. The author does not move the reader like in her previous books. You do not learn much from this book either. So, it felt like lost time of picking it up. I am glad that the writer came up with some important thoughts at the end that spoke to the reader.I hope to see more of that talent in her future books.I hope that the writer will not try to kill someone at the beginning of the book as well. She seemed to choose death to start each book of the series. With the last book, it was somehow annoying.I was going to read "Inheritance" next by the same writer, but the last book of this series made me very hesitant of picking out another by the same author.

A young French woman comes to America looking for her father whom she hasn't seen in over 20 years. He came over here to work as a trapper. She hires a driver and buys a wagon The driver is a great guy. They spent a long time going from one place to another looking for him. It's a great love story with loveable characters. The story is full of adventure

WONDERFUL 3rd book in the Fountain Creek Cronicles series, but can be read alone. I HIGHLY recommend this book and the series and actually anything by this author!! She is my ABSOLUTE FAVORITE AUTHOR!!!! I've read 8 of her books and they are all GREAT! Although I would normally have not chosen a pioneer setting to read, Ms Alexander's historical fiction will have you captivated at the very start!

I so enjoyed reading the final story of Fountain Creek/Willow Springs. Each story is unique but touches the other in a fascinating way. The characters each carry a memorable weight not easily forgotten. Thank you for the work you put into these stories, Mrs. Alexander. I totally enjoyed myself.

I tried one book by Tamera Alexander and the next thing I knew, I was loading each and every one in the Fountain Creek Chronicles! Each book gets better and better with a general overview from people met in the previous books. Always a completely new person added to the story with excellent plots and very, very well written stories.I won't give anything away but this book is a must read! I'm presently awaiting another new book and have read these all so quickly. They are the type of books which you can't put down for long. Thank You Tamera for your wonderfully written books. I've enjoyed each and every one of them.

A beautiful story ending this series. All three books are worth reading , captivating, romantic, and mysterious. These are definite keepers.

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